University of Pennsylvania · GeneticsThe Sweat Gland Initiative
Yana G Kamberov · Philadelphia, Pennsylvania
Research Focus
Dr. Yana G. Kamberov's lab studies the development of the eccrine sweat glands, which are crucial for regulating body temperature in humans. They focus on a specific type of dermal cell that plays a key role in the formation and function of these glands. By understanding the mechanisms involved in eccrine gland development, the lab aims to find ways to regenerate these glands, which can be important for people who have suffered skin injuries.
sweat glandsthermoregulationdermal nichecell differentiationgenetic perturbationsskin regenerationtranscriptomicscell lineagefunctional assays
Research Aims
4AIM 01Define the cellular mediators required for the induction, differentiation, and maintenance of the eccrine dermal niche.
AIM 02Identify the molecular effectors produced by the eccrine dermal niche that are necessary for eccrine gland differentiation.
AIM 03Understand the mechanisms of ectopic expression and gene regulation associated with eccrine gland development.
AIM 04Investigate the functional properties of the Engrailed 1-dependent eccrine niche in mouse models.
Skills the Lab Values
PCRsingle cell transcriptomicsin vivo genetic testingmouse modelscell culturehigh-throughput seqFISHgenetic disruptiontranscript analysislineage tracing
Output against the department
Publications24bottom 2% of dept.253rd of 259
this lab
most publishedleast published
Citations813bottom 3% of dept.251st of 259
this lab
most citedleast cited
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