Stanford University · BiophysicsChloride Channel Research Unit
Merritt C Maduke · Stanford, California
Research Focus
Merritt C Maduke's lab focuses on understanding chloride channels, particularly the CLC-Ka channel in the kidney, which plays a vital role in regulating water and solute balance in the body. They aim to develop specific inhibitors for this channel, which could lead to new treatments for conditions like hyponatremia that affect kidney function. By combining advanced structural biology techniques with medicinal chemistry, the lab seeks to create effective drugs that could improve patient outcomes in various kidney-related diseases.
chloride channelskidney functiondrug developmentcryo-electron microscopymedicinal chemistry
Research Aims
4AIM 01Develop specific inhibitors of the CLC-Ka channel.
AIM 02Utilize cryo-electron microscopy to determine the structure of CLC-Ka.
AIM 03Optimize drug candidates for potency and selectivity.
AIM 04Test the efficacy of inhibitors in animal models.
Skills the Lab Values
PCRcell culturecryogenic electron microscopymolecular dockingin vivo testingpharmacokinetic analysisstructure-function analysisprotein purificationmedicinal chemistry synthesis
Output against the department
Publications108bottom 30% of dept.7th of 10
this lab
most publishedleast published
Citations2.1kbottom 10% of dept.9th of 10
this lab
most citedleast cited
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