University of Virginia-Main Campus · GeneticsThe RNA Network Lab
John Platig · Charlottesville, Virginia
Research Focus
Dr. John Platig's research lab focuses on understanding the role of RNA binding proteins in Chronic Obstructive Pulmonary Disease (COPD), a major global health concern. The lab investigates how these proteins regulate RNA molecules and how disruptions in their networks can affect disease outcomes. By utilizing cutting-edge genomic and proteomic techniques, the team aims to uncover COPD-specific regulatory changes and their implications for cellular function, contributing to a better understanding of this debilitating disease.
Chronic Obstructive Pulmonary DiseaseRNA binding proteinspost-transcriptional regulationgenomic sequencingproteomicstranscriptomicsnetwork biology
Research Aims
3AIM 01Develop RBP-to-isoform regulatory networks using RNA binding assays and lung transcriptomic data.
AIM 02Characterize the functional impact of COPD-associated RBPs through knockdown experiments.
AIM 03Utilize long-read sequencing to identify differential isoforms in COPD lung samples.
Skills the Lab Values
RNA binding assayslong-read RNA sequencingmass spectrometrydata integrationbioinformaticsmolecular cloninggene knockdown techniquesdifferential expression analysisnetwork analysis
Output against the department
Publications94bottom 29% of dept.184th of 259
this lab
most publishedleast published
Citations2.7kbottom 14% of dept.222nd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.