University of California-San Francisco · NeuroscienceNeuroResilience Lab
Martin Kampmann · San Francisco, California
Research Focus
Dr. Martin Kampmann's lab at UCSF focuses on understanding the biological mechanisms behind Alzheimer's disease and related dementias. The lab investigates why certain neurons are more vulnerable to these diseases and explores potential therapeutic targets to improve resilience in these cells. They utilize advanced techniques including CRISPR and RNA sequencing to uncover the roles of specific genes and molecular pathways in neurodegeneration.
Alzheimer's diseasetauopathiesCRISPRineuron vulnerabilityRNA modificationsprotein homeostasisUFMylation pathwayIRE1 signalingm6A RNA
Research Aims
5AIM 01Elucidate molecular pathways controlling neuronal selective vulnerability to tauopathy.
AIM 02Investigate the role of the UFMylation pathway in regulating tau aggregation.
AIM 03Study the therapeutic potential of activating protective IRE1 signaling in tau model systems.
AIM 04Map m6A RNA modifications and their implications in Alzheimer’s disease.
AIM 05Identify candidate resilience factors in human neurons affected by Alzheimer's disease.
Skills the Lab Values
CRISPR interferencesingle-nucleus RNA sequencingcell culturemouse modelsgene knockdownquantitative PCRbioinformaticsprotein assaysimmunohistochemistry
Output against the department
Publications237top 31% of dept.207th of 671
this lab
most publishedleast published
Citations16ktop 25% of dept.167th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.