Case Western Reserve University · Biomedical EngineeringThe Elasticity Lab
Margot S. Damaser · Cleveland, Ohio
Research Focus
Dr. Margot S. Damaser’s lab focuses on developing innovative treatments for pelvic organ prolapse (POP), a condition that affects many women and can significantly impact their quality of life. The lab's main project investigates a novel drug delivery system using biodegradable nanomaterials to restore the elasticity of pelvic tissues, potentially preventing the progression of POP without invasive surgery. By combining advanced biomaterials with therapeutic agents, the lab aims to create effective and minimally invasive solutions for better women's health outcomes.
pelvic organ prolapsebiodegradable polymersnanomaterialsdrug deliveryelastic fibersECM homeostasisminimally invasive therapyregenerative medicinewomen's health
Research Aims
3AIM 01Investigate mechanisms of extracellular matrix restorative effects using drug formulations.
AIM 02Evaluate the additive regenerative benefits of nanomaterials and doxycycline in cell culture.
AIM 03Test the effects of nanomaterials in animal models of pelvic organ prolapse.
Skills the Lab Values
cell cultureanimal modelsmicroscopydrug formulationbiodegradable materials synthesistest method developmentmechanistic studiesbiomaterials evaluationin vivo testing
Output against the department
Publications286top 33% of dept.199th of 595
this lab
most publishedleast published
Citations5.9kbottom 45% of dept.325th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.