UMCUniversity of Massachusetts Chan Medical School · Biology
Aneuploidy and Cell Function Lab
Eduardo Martin Torres · Worcester, Massachusetts
Research Focus
Eduardo Martin Torres's lab investigates how an abnormal number of chromosomes affects cell function, particularly in Down syndrome. Their research seeks to understand the mechanisms that link aneuploidy (having an incorrect number of chromosomes) to developmental and aging-related issues in patients. The team focuses on cell structure, especially the nuclear membrane, to discover pathways that might help suppress negative effects associated with Down syndrome and promote health in affected individuals.
aneuploidyDown syndromecell biologynuclear morphologypremature agingcell homeostasischromosome 21biochemical pathwaysdevelopmental defectscognitive disability
Research Aims
5AIM 01Identify the mechanisms by which aneuploidy affects nuclear integrity.
AIM 02Investigate how abnormal nuclei contribute to the pathophysiology of trisomy 21.
AIM 03Target biochemical pathways to suppress aneuploidy-associated phenotypes.
AIM 04Elucidate cellular defects in Down syndrome independent of specific gene identity.
AIM 05Examine the relationship between aneuploidy and premature aging.
Skills the Lab Values
cell culturemicroscopywestern blotRNA sequencinggene expression analysiscell fractionationflow cytometrymass spectrometrybiochemical assays