Baylor College of Medicine · BiochemistryEfflux Pump Research Unit
Zhao Wang · Houston, Texas
Research Focus
Dr. Zhao Wang's lab at Baylor College of Medicine focuses on understanding how certain bacterial proteins known as efflux pumps help bacteria resist antibiotics. By studying the structure and assembly of these pumps using advanced imaging techniques, the lab aims to uncover the mechanisms behind multidrug resistance in pathogens like E. coli. This research is crucial for developing new strategies to combat antibiotic resistance, a significant public health threat.
multidrug resistanceefflux pumpsantibiotic resistanceE. colicryo-electron microscopy
Research Aims
4AIM 01Investigate the assembly process of efflux pumps in bacteria.
AIM 02Characterize the interaction between efflux pumps and antibiotics.
AIM 03Explore the role of the cell membrane environment in drug efflux.
AIM 04Develop strategies to inhibit efflux pumps in resistant bacteria.
Skills the Lab Values
cryogenic electron microscopybacterial culturebiochemical assaysgenetic manipulationprotein purification
Output against the department
Publications551top 7% of dept.30th of 402
this lab
most publishedleast published
Citations14ktop 33% of dept.134th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.