Baylor College of Medicine · BiologyThe Hematopoiesis Lab
Margaret A. Goodell · Houston, Texas
Research Focus
Dr. Margaret A. Goodell's lab focuses on understanding clonal hematopoiesis (CH), a pre-cancerous condition where certain blood cells expand due to genetic mutations. The lab investigates how different stressors, like inflammation and environmental factors, interact with these mutations to influence the risk of developing blood cancers. By using innovative mouse models and analyzing data from large human studies, their aim is to identify modifiable factors that could prevent the progression of CH into malignancies.
clonal hematopoiesishematologic malignanciesinflation stressgenotoxic stressepigenetic regulation
Research Aims
3AIM 01Identify cancer risk factors associated with clonal hematopoiesis.
AIM 02Examine how inflammatory stress influences genetic mutations in blood cells.
AIM 03Test potential interventions to suppress the expansion of harmful blood cell clones.
Skills the Lab Values
mouse modelssingle cell sequencingDNA sequencingbioinformaticsmetabolomic analysis
Output against the department
Publications428top 10% of dept.108th of 1,033
this lab
most publishedleast published
Citations35ktop 9% of dept.93rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.