University of Arkansas for Medical Sciences · Microbiology & ImmunologyLung Macrophage Research Lab
Lu Huang · Little Rock, Arkansas
Research Focus
Dr. Lu Huang's lab focuses on understanding how lung macrophages respond to tuberculosis infection. The research aims to uncover the mechanisms that make these cells permissive to the growth of the bacteria Mycobacterium tuberculosis, which causes TB. By exploring the origins and metabolic pathways of these immune cells, the lab hopes to develop new strategies and therapies to enhance the fight against TB.
tuberculosisMycobacterium tuberculosislung macrophagesmetabolic pathwaysimmunology
Research Aims
3AIM 01Determine how ontogeny contributes to the response of alveolar macrophages during Mtb infection.
AIM 02Delinate how glycolysis and fatty acid oxidation differentially regulate the permissiveness of macrophages during Mtb infection.
AIM 03Reprogram macrophages by leveraging their ontogeny and metabolism against Mtb infection.
Skills the Lab Values
cell culturegene expression analysismouse modelsflow cytometryimmunofluorescenceRNA sequencingmetabolomicsgenomicsimmunological assays
Output against the department
Publications181top 37% of dept.181st of 486
this lab
most publishedleast published
Citations6.5kbottom 47% of dept.257th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.