Dartmouth College · Microbiology & ImmunologyBliska Lab
James B Bliska · Hanover, New Hampshire
Research Focus
Dr. James B Bliska's lab at Dartmouth College studies how certain bacterial proteins can help pathogens avoid detection and destabilize the body's immune defenses. They focus on understanding how bacteria, like Yersinia, use specialized mechanisms to disrupt protective pathways in immune cells during infection. This research not only enhances our understanding of bacterial infections but also aims to inform new approaches to boost immune defenses against such pathogens.
type III secretionYersiniainflammasomebacterial virulenceinnate immunity
Research Aims
5AIM 01Investigate how type III secretion effectors inhibit inflamasome pathways in immune cells.
AIM 02Determine the cell-specific actions of Yersinia effectors YopM and YopJ during infections.
AIM 03Analyze the interaction between YopM and the pyrin domain to characterize its role in virulence.
AIM 04Assess the impact of IL-1b release on the immune response to Yersinia infections.
AIM 05Develop therapeutic strategies to enhance protective neutrophil responses against bacterial pathogens.
Skills the Lab Values
cell culturemolecular cloningprotein purificationWestern blottingin vivo mouse modelsimmunohistochemistryfluorescence microscopybioinformaticsPCRaffinity chromatography
Output against the department
Publications194top 33% of dept.160th of 486
this lab
most publishedleast published
Citations11ktop 32% of dept.154th of 486
this lab
most citedleast cited
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