Purdue University-Main Campus · BiochemistryCdc14 Phosphatase and Fungal Pathogens Lab
Mark C Hall · West Lafayette, Indiana
Research Focus
Dr. Mark C Hall's research lab at Purdue University focuses on understanding how a specific protein, Cdc14 phosphatase, affects the virulence and drug resistance of fungal pathogens, particularly Candida species. The lab explores how this protein influences cell wall integrity, fungal growth, and responses to antifungal drugs, with the aim of identifying new targets for antifungal therapies. By studying the molecular mechanisms behind Cdc14's role, the lab seeks to contribute to the development of effective treatments for life-threatening fungal infections, especially in immune-compromised patients.
Cdc14 phosphataseCandida aurisdrug resistancefungal pathogenscell wall integrityhyphal developmentvirulenceantifungal drug developmentphosphoregulationproteomics
Research Aims
3AIM 01Characterize how Cdc14 regulates cell wall integrity and septation in Candida albicans.
AIM 02Investigate the regulation of hyphal initiation and maintenance by Cdc14.
AIM 03Understand the mechanisms by which Cdc14 is regulated by cell wall stress and hypha-inducing signals.
Skills the Lab Values
cell culturemouse modelsquantitative phosphoproteomicsbiochemical assayscell biological assaysgenetic transcription analysisstructure-function analysisunbiased omics approachesbiochemical analysisinfectious disease modeling
Output against the department
Publications178top 48% of dept.191st of 402
this lab
most publishedleast published
Citations3.6kbottom 18% of dept.330th of 402
this lab
most citedleast cited
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