University of Florida · Microbiology & ImmunologyDoore Phage Lab
Sarah M Doore · Gainesville, Florida
Research Focus
Dr. Sarah M. Doore's lab at the University of Florida focuses on understanding how bacteriophages, which are viruses that infect bacteria, interact with their hosts. The lab specifically studies a group of bacteriophages called Moogleviruses that target pathogenic bacteria responsible for diarrhea. By exploring the mechanisms of infection and replication of these viruses, the research aims to develop new strategies for phage therapy, particularly in combating antibiotic-resistant infections.
bacteriophagesMooglevirusesantibiotic resistanceShigella flexneriphage therapyviral-host interactionsgene expressiontranslational regulationbacterial infections
Research Aims
5AIM 01Investigate how Moogleviruses identify and bind to their bacterial hosts.
AIM 02Determine the effects of Mooglevirus infection on the expression of both viral and host genes.
AIM 03Characterize the assembly process of Mooglevirus capsids and their stability in various conditions.
AIM 04Explore the environmental persistence of Moogleviruses and their potential use in clinical settings.
AIM 05Assess the potential of Moogleviruses for developing treatments for antibiotic-resistant infections.
Skills the Lab Values
PCRRNA sequencingcell culturebiochemical assaysCryo-electron microscopygenomic analysisbioinformaticsviral propagationdata analysis
Output against the department
Publications31bottom 5% of dept.461st of 486
this lab
most publishedleast published
Citations358bottom 3% of dept.471st of 486
this lab
most citedleast cited
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