University of California-San Francisco · NeuroscienceZamvil Immunology Lab
Scott S Zamvil · San Francisco, California
Research Focus
Dr. Scott Zamvil's lab at UCSF focuses on understanding how immune system cells, particularly T cells and B cells, contribute to a condition known as MOG antibody-associated disease (MOGAD). This research aims to uncover the roles of these cells in causing damage to the central nervous system and explore potential new treatments. By studying how these immune responses develop and interact, the lab hopes to advance our knowledge of various autoimmune disorders.
MOG antibody-associated diseaseT cellsB cellsautoimmune diseasesCNS injuryEAE modelpatient-derived cellsimmune response
Research Aims
4AIM 01Identify and characterize MOG-specific T cells in patients with different MOGAD phenotypes.
AIM 02Evaluate how B cell antigen presentation shapes the pathogenic MOG-specific T cell repertoire.
AIM 03Characterize MOG-specific T cell and humoral responses in humanized MOG knock-in mice.
AIM 04Investigate the pathogenic potential of serum MOG-specific antibodies from MOGAD patients.
Skills the Lab Values
single cell RNA sequencingperipheral blood mononuclear cell isolationmouse modelsimmunohistochemistrypeptide stimulation assaysflow cytometryB cell receptor analysisMOG protein immunizationhumanized mouse models
Output against the department
Publications305top 22% of dept.146th of 671
this lab
most publishedleast published
Citations23ktop 18% of dept.119th of 671
this lab
most citedleast cited
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