Thomas Jefferson University · PharmacologyWaldman Pain Lab
Scott A. Waldman · Philadelphia, Pennsylvania
Research Focus
Dr. Scott A. Waldman's lab focuses on understanding and targeting visceral pain, particularly related to disorders like irritable bowel syndrome and chronic constipation. They study the role of specific intestinal cells and hormones in regulating nerve activity that contributes to pain, with the aim of developing new, more effective pain relief therapies without major side effects. By investigating a novel signaling pathway in the gut, they hope to translate their findings into innovative treatments for patients suffering from chronic visceral pain.
visceral paingut-brain interactionGUCY2C receptorintestinal neuropod cellschronic painirritable bowel syndromehormonal signalingpain management
Research Aims
4AIM 01Investigate the mechanisms behind visceral hypersensitivity in the gut.
AIM 02Identify the role of GUCY2C signaling in pain regulation.
AIM 03Explore the relationship between intestinal hormones and nerve excitability.
AIM 04Develop novel therapeutic approaches to alleviate chronic visceral pain without side effects.
Skills the Lab Values
cell culturemouse modelsneuroscience techniquespain assessmentmolecular biology techniquesWestern blottingimmunohistochemistrysignal transduction analysisoral drug formulation
Output against the department
Publications591top 7% of dept.34th of 462
this lab
most publishedleast published
Citations18ktop 20% of dept.93rd of 462
this lab
most citedleast cited
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