University of Arizona · PhysiologyHay Cognitive Lab
Meredith Hay · Tucson, Arizona
Research Focus
Dr. Meredith Hay's research lab focuses on developing new treatments for cognitive impairment, particularly in patients at risk for vascular dementia and Alzheimer's disease. The lab is working on a peptide called PNA5, which has shown promise in reducing inflammation and improving brain blood flow to restore cognitive function. Through various studies, they aim to prepare PNA5 for clinical trials that could lead to new therapies for these debilitating conditions.
vascular dementiaAlzheimer's diseasecognitive impairmentanti-inflammatory peptidesclinical trials
Research Aims
5AIM 01Conduct toxicology studies to assess safety of PNA5
AIM 02Manufacture PNA5 for clinical trials
AIM 03Prepare FDA documentation for Phase 2 trials
AIM 04Evaluate the effects of PNA5 on cognitive function
AIM 05Study the brain penetration of PNA5 in preclinical models
Skills the Lab Values
toxicology studiesGMP manufacturingphase 2 clinical trial designcerebral blood flow assessmentdrug formulation
Output against the department
Publications155top 48% of dept.137th of 286
this lab
most publishedleast published
Citations4.0kbottom 33% of dept.193rd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.