RUThe Rockefeller University · Biology
Funabiki Lab
Hironori Funabiki · New York, New York
Research Focus
Dr. Hironori Funabiki's lab at Rockefeller University focuses on understanding how chromosomes are inherited and maintained during cell division, processes that are crucial for preventing diseases like cancer. The lab utilizes innovative techniques involving Xenopus egg extracts to study the structure and regulation of nucleosomes, which are essential for the integrity of our genetic material. Through their research, they aim to uncover the roles of specific proteins in maintaining chromosome stability and preventing immune responses that could lead to cell death.
chromosome inheritancenucleosomescell divisioncancerinnate immunityXenopus egg extractsDNA methylationmolecular biologycyclic GMP-AMPmitosis
Research Aims
3AIM 01Investigate the role of nucleosomes in maintaining chromosome structure and function during mitosis.
AIM 02Dissect the molecular mechanisms of CDCA7 and HELLS in chromatin remodeling and their relation to cancers.
AIM 03Understand how cGAS is regulated during cell division to prevent unwanted immune responses.
Skills the Lab Values
cryogenic electron microscopy (cryo-EM)nucleosome manipulationDNA extraction and analysiscell culturemolecular cloningprotein expressionimmunoprecipitationWestern blottingRNA extractionflow cytometry
Output against the department
Publications91bottom 30% of dept.723rd of 1,033
this lab
most publishedleast published
Citations8.7ktop 44% of dept.453rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.