Columbia University in the City of New York · BiochemistryIon Channel Structure and Function Lab
Alexander Sobolevsky · New York, New York
Research Focus
Dr. Alexander Sobolevsky's lab focuses on understanding the structure and function of important proteins involved in sensory signaling and neurotransmission. His research primarily targets two classes of ion channels: the TRPV3 channel, which is involved in skin sensations and several skin diseases, and ionotropic glutamate receptors (iGluRs), which are crucial for communication in the brain. By exploring how these channels work at a molecular level, the lab aims to lay the groundwork for developing better treatments for various health conditions.
TRPV3ionotropic glutamate receptorsskin diseasesexcitatory neurotransmissionmolecular signaling
Research Aims
5AIM 01Investigate the molecular mechanisms of TRPV3 activation by small molecules and mutations.
AIM 02Determine the structural bases of TRPV3 activation by temperature.
AIM 03Elucidate the mechanisms of TRPV3 inhibition.
AIM 04Study the structures of heteromeric iGluRs for better understanding of their function.
AIM 05Uncover the molecular basis of noncompetitive inhibition of iGluRs.
Skills the Lab Values
cryo-electron microscopymutagenesiselectrophysiologycalcium imagingprotein purificationWestern blotcell culturebiochemical assaysstructural biology
Output against the department
Publications206top 39% of dept.157th of 402
this lab
most publishedleast published
Citations7.3kbottom 40% of dept.242nd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.