University of Texas Southwestern Medical Center · Microbiology & ImmunologyPfeiffer Lab
Julie K Pfeiffer · Dallas, Texas
Research Focus
Dr. Julie K. Pfeiffer's lab studies how intestinal microbiota affect the infection of enteric viruses, like reoviruses. The research looks at how different strains of these viruses interact with gut bacteria and how those interactions can either enhance or inhibit viral replication. This work aims to uncover the complex relationships between viruses and the gut microbiome, which could lead to new insights into combating viral infections.
enteric virusesmicrobiotaviral infectionreovirusgut microbiomeviral replicationimmune response
Research Aims
5AIM 01Examine the specificity of reovirus-glycan interactions.
AIM 02Determine how microbiota facilitate infection with reovirus strain T3SA+.
AIM 03Elucidate mechanisms of microbiota inhibition of reovirus strain T3SA-.
AIM 04Investigate the effects of microbiota on different strains of reoviruses.
AIM 05Explore the relationship between enteric viruses and gut microbiota.
Skills the Lab Values
cell culturemouse modelsin vitro experimentationimmunological assaysmolecular cloningPCRWestern blotRNA sequencingglycan analysis
Output against the department
Publications128bottom 48% of dept.251st of 486
this lab
most publishedleast published
Citations4.1kbottom 31% of dept.336th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.