SLUSaint Louis University · Biochemistry
Mitochondrial Gateway Lab
Kyle S Mccommis · Saint Louis, Missouri
Research Focus
The McCommis lab at Saint Louis University focuses on understanding how the mitochondrial pyruvate carrier (MPC) works and its role in cellular metabolism. They conduct experiments using both in vitro techniques and genetic mouse models to uncover the structural dynamics of the MPC. Their research aims to reveal how this transporter contributes to energy production and metabolic regulation, particularly in the context of diseases like diabetes and cardiometabolic disorders.
mitochondrial metabolismpyruvate transportmetabolic regulationbiochemical techniquesin vivo models
Research Aims
5AIM 01Investigate the structural dynamics of the mitochondrial pyruvate carrier during transport.
AIM 02Determine factors that regulate MPC activity using biochemical methods.
AIM 03Explore the effects of cardiolipin composition on MPC function.
AIM 04Assess the role of specific metabolites in inhibiting pyruvate metabolism.
AIM 05Use genetic mouse models to study metabolic diseases related to MPC.
Skills the Lab Values
DEER spectroscopybiochemical assaysmouse modelsprotein purificationcell culture
Output against the department
Publications125bottom 35% of dept.262nd of 402
this lab
most publishedleast published
Citations2.9kbottom 14% of dept.347th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.