Tufts University · NeuroscienceNeuroactive Steroid Research Lab
Stephen J Moss · Medford, Massachusetts
Research Focus
Dr. Stephen J. Moss's lab at Tufts University focuses on understanding how neuroactive steroids affect brain function, particularly through a family of receptors known as G-protein coupled receptors. These steroids can influence behavior and may offer new treatments for mental health issues like postpartum depression. The lab uses various techniques to explore how these compounds mediate their effects on neuronal excitability and might lead to innovative strategies for improving mental health.
G-protein coupled receptorsneuroactive steroidsneurosteroidsbrain signalingneuronal excitabilitypostpartum depressionmental healthtonic inhibitionGABAARs
Research Aims
4AIM 01Examine how neuroactive steroids influence intracellular signaling through G-protein coupled receptors.
AIM 02Determine the specific role of different membrane progesterone receptors in mediating the effects of neuroactive steroids.
AIM 03Investigate the impact of chronic neuroactive steroid exposure on neuronal inhibition and GABA receptor composition.
AIM 04Assess how neuroactive steroids regulate neuronal excitability through receptor activation.
Skills the Lab Values
cell culturegene editingmolecular biology techniquesbehavioral assays in micesignal transduction analysispharmacological testingimmunofluorescence microscopyprotein analysiscAMP assays
Output against the department
Publications289top 24% of dept.159th of 671
this lab
most publishedleast published
Citations26ktop 15% of dept.101st of 671
this lab
most citedleast cited
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