Washington University in St Louis · BiologyThe Lymphatic Brain Initiative
Jonathan Kipnis · Saint Louis, Missouri
Research Focus
Dr. Jonathan Kipnis's lab at Washington University focuses on understanding how the immune system influences brain function and contributes to age-related cognitive decline and diseases like Alzheimer's. The research explores the role of meningeal lymphatics and immune cells in maintaining cognitive health, especially in older adults. The lab aims to develop innovative treatments that may enhance brain health by modulating immune responses.
Alzheimer's DiseaseCognitive DeclineMeningeal LymphaticsNeuroimmunologyCAR T Cell TherapyAgingInnate ImmunityCytokinesNeuroprotection
Research Aims
3AIM 01Investigate how dysfunction of meningeal lymphatics affects cognitive decline with age.
AIM 02Characterize changes in meningeal immune cells due to age-related vascular dysfunction.
AIM 03Develop CAR T cell therapies targeting Alzheimer's pathology to protect neuronal function.
Skills the Lab Values
Animal ModelsImmunohistochemistryFlow CytometryMolecular CloningCell CultureSurgical Techniques in MiceIn Vivo ImagingCytokine AssaysCAR T Cell Engineering
Output against the department
Publications312top 18% of dept.181st of 1,033
this lab
most publishedleast published
Citations37ktop 8% of dept.81st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.