Icahn School of Medicine at Mount Sinai · GeneticsBrown RNA Lab
Brian D Brown · New York, New York
Research Focus
Dr. Brian D Brown's lab at the Icahn School of Medicine focuses on developing advanced RNA-based therapeutics, specifically modRNA (modified RNA), which can be used to improve vaccine responses and treat diseases. They are investigating how to control which types of cells produce proteins from modRNA, with the goal of enhancing the immune response to vaccines and potentially manipulating how the body tolerates certain proteins. This research is particularly relevant for developing more effective vaccines and therapies that target specific cells in the body.
modRNAvaccine developmentlipid nanoparticlesimmune responsemicroRNAantigen presentationdrug deliverytherapeuticscell type specificity
Research Aims
5AIM 01Investigate the impact of different cell types on the immune response to modRNA-encoded proteins.
AIM 02Develop modRNA formulations with targeted expression in specific cell types.
AIM 03Characterize the role of microRNA in regulating modRNA expression in various cell types.
AIM 04Assess how modRNA presentation by non-antigen-presenting cells affects vaccine efficacy.
AIM 05Explore new therapeutic approaches using modRNA for immune modulation.
Skills the Lab Values
mRNA designlipid nanoparticle formulationcell culture techniquesflow cytometryimmunophenotypingCRISPR technologyanimal modelsRNA sequencingdata analysis in immunology
Output against the department
Publications247top 34% of dept.88th of 259
this lab
most publishedleast published
Citations18ktop 32% of dept.82nd of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.