University of Texas Southwestern Medical Center · Microbiology & ImmunologyWu Lab
Tuoqi Wu · Dallas, Texas
Research Focus
Dr. Tuoqi Wu's lab focuses on understanding how specific immune cells, called CD8 T cells, respond to chronic viral infections like HIV, HBV, and HCV. Their research aims to enhance the immune response against these viruses by investigating different types of CD8 T cells, particularly a special group that is more effective in fighting infections. By uncovering the mechanisms that allow these cells to maintain their functionality over time, they hope to develop new strategies to improve immunotherapies for chronic infections.
CD8 T cellschronic viral infectionantiviral immunityT cell exhaustionimmunotherapyHIVHBVHCVmetabolismcell signaling
Research Aims
5AIM 01Investigate the mechanisms that lead to CD8 T cell dysfunction during chronic viral infection.
AIM 02Identify the properties of stem-like CD8 T cells that enhance their antiviral response.
AIM 03Develop strategies to rejuvenate exhausted CD8 T cells to improve immune responses.
AIM 04Evaluate the effectiveness of various immunotherapies on stem-like CD8 T cells.
AIM 05Explore metabolic pathways that support the function of antiviral T cells.
Skills the Lab Values
Cell cultureFlow cytometryMouse modelsMetabolic assaysMolecular cloningImmunological assaysPCRBiochemical assaysTranscriptional profilingImaging techniques
Output against the department
Publications72bottom 22% of dept.380th of 486
this lab
most publishedleast published
Citations3.2kbottom 22% of dept.377th of 486
this lab
most citedleast cited
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