University of Colorado Boulder · EngineeringAdvanced Biomaterials and Tissue Engineering Lab
Kristi S. Anseth · Boulder, Colorado
Research Focus
Dr. Kristi Anseth's lab focuses on the development of advanced materials and models to study complex biological processes related to the intestine and heart valves. By using innovative hydrogels, the lab investigates how the structure of tissues influences cellular behavior and health, particularly under injury or disease conditions. The research aims to improve our understanding of important processes like crypt regeneration in the intestine and the differences in heart valve disease prevalence between sexes.
hydrogelsintestinal organoidscrypt fissionheart valve diseasesex differencesinflammationtissue engineeringbiomaterialscell signaling
Research Aims
4AIM 01Investigate the role of cell-matrix interactions in intestinal crypt formation.
AIM 02Develop in vitro models to study sex-specific responses in valve disease.
AIM 03Explore the mechanisms of crypt fission in intestinal organoids.
AIM 04Identify therapies targeting fibro-calcification in heart valves.
Skills the Lab Values
hydrogel fabrication3D cell cultureintestinal organoid model generationmicroscopycellular signaling assaysbiochemical assaysdata analysis using Pythontissue staining techniquesanimal modeling
Output against the department
Publications594top 7% of dept.19th of 278
this lab
most publishedleast published
Citations57ktop 4% of dept.12th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.