Columbia University in the City of New York · GeneticsDNA Repair and Immunotherapy Unit
Alberto Ciccia · New York, New York
Research Focus
Professor Alberto Ciccia's lab at Columbia University focuses on understanding how certain DNA repair mechanisms can influence cancer immunotherapy. By studying the role of the DNA translocase SMARCAL1, the lab aims to uncover how tumors evade the immune system and improve the effectiveness of treatments that rely on anti-tumor immune responses. Their research combines genetics, biochemistry, and animal models to explore the intricate relationships between DNA damage response and immune signaling.
DNA damage responsecancer immunotherapyimmune checkpoint blockadeSMARCAL1tumor immune evasion
Research Aims
3AIM 01Define how SMARCAL1 suppresses innate immune signaling in cancer cells.
AIM 02Investigate the mechanisms by which SMARCAL1 regulates PD-L1 expression.
AIM 03Identify novel DNA damage response factors that impact anti-tumor immunity.
Skills the Lab Values
cell culturegenetic screeningbiochemical assaysanimal modelsflow cytometry
Output against the department
Publications134bottom 42% of dept.149th of 259
this lab
most publishedleast published
Citations11ktop 47% of dept.121st of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.