University of Florida · PhysiologyGumz Lab
Michelle L Gumz · Gainesville, Florida
Research Focus
Dr. Michelle Gumz's lab studies how our body's internal clock influences blood pressure and kidney function. They focus on a key protein called PER1, which helps regulate these functions. By understanding how disruptions in this clock can lead to conditions like salt-sensitive hypertension and kidney disease, the lab aims to find new treatments to help patients with cardiovascular issues.
circadian rhythmsPER1salt-sensitive hypertensionkidney diseasealdosterone signalingmineralocorticoid receptorendothelin-1therapeuticsclock proteinsblood pressure regulation
Research Aims
5AIM 01Evaluate how loss of PER1 affects aldosterone signaling and blood pressure regulation.
AIM 02Investigate the protective effects of PER1 on kidney function under salt-sensitive conditions.
AIM 03Explore the potential of increasing PER1 expression as a therapeutic option for hypertension.
AIM 04Determine the role of PER1 in mediating adrenal hormone production.
AIM 05Understand the mechanisms by which circadian clock components influence kidney health.
Skills the Lab Values
molecular biology techniquesgenetic knockout modelspharmacological interventionsgene therapykidney transplantation modelsrodent handlingassessing blood pressurerenal function assayssignal transduction analysisdata visualization with software
Output against the department
Publications180top 37% of dept.106th of 286
this lab
most publishedleast published
Citations4.3kbottom 36% of dept.183rd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.