Johns Hopkins University · ChemistryGoldberg Lab
David P Goldberg · Baltimore, Maryland
Research Focus
Dr. David P Goldberg's lab at Johns Hopkins University focuses on studying how certain metal-containing enzymes activate oxygen and oxidize various substrates. By creating synthetic versions of these enzymes, the lab aims to better understand the chemical processes involved in important biological reactions that can impact human health, including those related to diseases like cancer and neurodegenerative disorders.
metalloenzymesdioxygen activationhemenonhemeoxidation mechanismssynthetic biologybiomimeticsenzyme catalysisreactivity studiestransition metal complexes
Research Aims
5AIM 01Investigate how heme and nonheme iron centers activate dioxygen.
AIM 02Characterize the intermediates involved in oxygen activation by metal complexes.
AIM 03Examine the influence of ligand structure on substrate oxidation.
AIM 04Establish structure-activity relationships for transition metal complexes.
AIM 05Explore the relevance of these processes to human health and disease.
Skills the Lab Values
synthesis of metal complexeskinetic studiesthermodynamic analysisspectroscopic characterizationreaction mechanism analysiscrystallography techniqueschemical modification of ligandsOxidation-reduction reactionsmolecular modelingbiomimetic design
Output against the department
Publications332top 34% of dept.73rd of 216
this lab
most publishedleast published
Citations42ktop 9% of dept.19th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.