University of Alabama at Birmingham · BiologyThe ZTTK Research Initiative
Erin Eun-Young Ahn · Birmingham, Alabama
Research Focus
Dr. Erin Eun-Young Ahn's lab focuses on understanding a rare genetic disorder known as Zhu-Tokita-Takenouchi-Kim (ZTTK) syndrome, which affects children and leads to serious hematopoietic and immune system disorders. The lab uses mouse models to explore the molecular mechanisms and genetic factors that contribute to these abnormalities, ultimately aiming to improve diagnosis and treatment for affected families. Their research highlights the importance of recognizing and studying rare diseases that often go unnoticed in the broader medical community.
ZTTK syndromehematopoietic disordersrare genetic diseasesmouse modelsmolecular mechanisms
Research Aims
5AIM 01Investigate how Son haploinsufficiency affects functional output of hematopoietic stem cells.
AIM 02Dissect the molecular mechanisms leading to hematopoietic abnormalities in ZTTK syndrome.
AIM 03Characterize the expression and splicing of chromatin modifiers in affected cells.
AIM 04Develop strategies to improve clinical recognition of rare diseases.
AIM 05Advance therapeutic approaches for treating ZTTK syndrome.
Skills the Lab Values
RNA sequencingmouse modelshematopoietic stem cell analysiscell culturegenetic analysis
Output against the department
Publications141top 49% of dept.503rd of 1,033
this lab
most publishedleast published
Citations2.0kbottom 15% of dept.882nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.