North Carolina State University at Raleigh · BiologyGastric Cell Biology Lab
Michele A Battle · Raleigh, North Carolina
Research Focus
Dr. Michele A Battle's lab focuses on understanding how gastric parietal cells function in the stomach. These cells are crucial for secreting acid and assisting with digestion. The lab is particularly interested in a protein called GATA4, which helps regulate how these cells work. By studying the roles of GATA4 and its effects on gastric health, the research has the potential to inform treatments for conditions like ulcers and gastric cancer.
GATA4gastric parietal cellsgastric acid secretioncellular biologygastric diseasesmetaplasiatranscription factorshuman organoids
Research Aims
4AIM 01Define the role of GATA4 in gastric parietal cell function.
AIM 02Investigate how GATA4 overexpression affects gastric injury recovery.
AIM 03Examine the relationship between GATA4 and gastric metaplasia.
AIM 04Study the evolutionary conservation of GATA4 function in human gastric organoids.
Skills the Lab Values
conditional mouse modelsgene expression analysismolecular biology techniqueshistologycell culturePCRorganoid cultureimmunohistochemistry
Output against the department
Publications63bottom 17% of dept.861st of 1,033
this lab
most publishedleast published
Citations4.2kbottom 32% of dept.705th of 1,033
this lab
most citedleast cited
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