University of North Carolina at Chapel Hill · BiologyFlick Lab
Matthew J. Flick · Chapel Hill, North Carolina
Research Focus
Dr. Matthew J. Flick's lab investigates how blood clots form and how to prevent excessive clotting, which can lead to serious health issues like heart attacks and strokes. The team studies an important protein called fibrinogen, aiming to develop new therapies that reduce the risk of thrombosis while keeping the body’s ability to stop bleeding intact. Their research is crucial for improving public health outcomes related to blood clotting disorders.
thrombosisfibrinogenblood clotssiRNAinflammationhemostasisfibrin matrixvenous thrombosisarterial thrombosis
Research Aims
3AIM 01Explore how lowering fibrinogen levels affects blood clot formation.
AIM 02Assess the impact of fibrin matrix suppression on hemostatic processes.
AIM 03Investigate the role of targeted therapies in controlling thrombosis during inflammation and disease.
Skills the Lab Values
lipid nanoparticle technologysmall interfering RNA (siRNA) deliverymRNA delivery systemsblood coagulation assaysplatelet function analysisanimal modelsanti-inflammatory techniquesmolecular cloningbiostatistical analysis
Output against the department
Publications232top 26% of dept.272nd of 1,033
this lab
most publishedleast published
Citations10ktop 37% of dept.386th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.