University of Iowa · NeuroscienceEpilepsy Arousal Dynamics Lab
Gordon F Buchanan · Iowa City, Iowa
Research Focus
Dr. Gordon F Buchanan's lab at the University of Iowa focuses on understanding how seizures affect the brain's ability to respond to carbon dioxide, which may play a role in sudden unexpected death in epilepsy (SUDEP). By using advanced mouse models, the lab investigates the mechanisms of arousal impairment surrounding seizures and explores potential therapeutic interventions to mitigate risks associated with epilepsy.
epilepsySUDEParousal mechanismscarbon dioxidemouse modelsseizuresneurobiologytemporal lobe epilepsyoptogenetics
Research Aims
3AIM 01Determine the extent to which carbon dioxide-induced arousal is impaired in mouse models of epilepsy.
AIM 02Assess neuronal function in key regions of the brain associated with arousal regulation during seizures.
AIM 03Explore the effects of optogenetic stimulation on preventing seizure-induced death in mouse models of Dravet Syndrome.
Skills the Lab Values
fiber photometrymouse modelsoptogeneticselectroencephalographydata analysisbehavioral assaysanimal handlingphotometry techniquescellular imaging
Output against the department
Publications88bottom 28% of dept.485th of 671
this lab
most publishedleast published
Citations3.2kbottom 24% of dept.511th of 671
this lab
most citedleast cited
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