New York University · NeuroscienceSalzer Neurobiology Lab
James Salzer · New York, New York
Research Focus
Dr. James Salzer's lab at NYU focuses on understanding how Schwann cells, which support and insulate nerve fibers, influence the health and function of axons. By studying genetically modified mice, the lab investigates how defects in Schwann cells lead to neurodegenerative diseases, particularly focusing on the mechanisms behind conditions like Charcot-Marie-Tooth disease. The research has the potential to reveal new treatment approaches for peripheral nerve disorders that result from Schwann cell dysfunction.
Schwann cellsaxonal functionCharcot-Marie-Tooth diseaseneurodegenerationinflammationmyelinationneuropathygenetic modificationperipheral nervous system
Research Aims
5AIM 01Investigate the impact of Schwann cell pathology on axon structure.
AIM 02Understand the role of inflammation in Schwann cell-related diseases.
AIM 03Characterize the differences between various mutant Schwann cells.
AIM 04Examine how mutations in Schwann cell proteins affect nerve conduction.
AIM 05Identify potential therapeutic strategies for neurological disorders.
Skills the Lab Values
cell culturemouse modelsgenetic engineeringRNA sequencinginflammation assaysneurophysiology techniquesWestern blotimmunofluorescence microscopydata analysis in biological research
Output against the department
Publications141bottom 49% of dept.342nd of 671
this lab
most publishedleast published
Citations13ktop 32% of dept.212th of 671
this lab
most citedleast cited
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