The University of Texas Medical Branch at Galveston · BiochemistryIwahara Proteomics Lab
Junji Iwahara · Galveston, Texas
Research Focus
Dr. Junji Iwahara's lab at the University of Texas Medical Branch focuses on understanding how proteins interact with DNA, which is vital for regulating gene expression and maintaining genomic integrity. The lab uses advanced techniques like nuclear magnetic resonance (NMR) to study the dynamic processes through which DNA-binding proteins locate and recognize their target sites on DNA. These insights are crucial for developing new therapies for diseases linked to dysfunctional DNA-binding proteins.
DNA-binding proteinsprotein-DNA interactionsNMR spectroscopyelectrostaticsintrinsically disordered regionsgene expressiontherapeuticsbiophysical techniquesdynamic behaviormolecular scanning
Research Aims
5AIM 01Investigate how DNA-binding proteins navigate obstacles on DNA.
AIM 02Examine the role of intrinsically disordered regions in protein-DNA interactions.
AIM 03Explore the electrostatic influences of post-translational modifications on DNA-binding proteins.
AIM 04Analyze the dynamics of counterions surrounding DNA and proteins.
AIM 05Develop therapeutic strategies based on the dynamics of protein-DNA interactions.
Skills the Lab Values
NMR spectroscopystopped-flow fluorescenceprotein purificationelectrophoresisdata analysis using Pythoncell culture techniquesmolecular modelingbiophysical characterizationcrystal structure determinationspectroscopy techniques
Output against the department
Publications128bottom 36% of dept.256th of 402
this lab
most publishedleast published
Citations6.1kbottom 35% of dept.261st of 402
this lab
most citedleast cited
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