Temple University · BiologyBarrier Function and Therapeutics Unit
Yuri Persidsky · Philadelphia, Pennsylvania
Research Focus
Dr. Yuri Persidsky's lab focuses on how substances like alcohol and electronic cigarettes can damage the blood-brain barrier and lung functions. They study what happens at the cellular level during this damage and explore potential therapeutic interventions. Their work is crucial for understanding the long-term effects of these substances, particularly in adolescents, who are significant users of e-cigarettes.
blood-brain barrieralveolar-endothelial barrierelectronic cigarettesalcohol use disorderpurinergic receptor signalingneuroinflammation3D in vitro modelscellular mechanismsanimal modelstherapeutic interventions
Research Aims
3AIM 01Evaluate how e-cigarettes and alcohol together affect the blood-brain barrier.
AIM 02Investigate cellular mechanisms of lung injury from alcohol and e-cigarette exposure.
AIM 03Measure the impact on cognition and inflammation during combined exposures.
Skills the Lab Values
3D cell cultureimmunohistochemistrybronchoalveolar lavageanimal handlingneuroinflammation assaysmitochondrial function assessmentmolecular biology techniquesdata analysis in biomedical researchpermeability assaysflow cytometry
Output against the department
Publications174top 38% of dept.392nd of 1,033
this lab
most publishedleast published
Citations13ktop 28% of dept.293rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.