UMCUniversity of Massachusetts Chan Medical School · Biochemistry
Schiffer Drug Resistance Lab
Celia A. Schiffer · Worcester, Massachusetts
Research Focus
Dr. Celia A. Schiffer's lab focuses on understanding and preventing drug resistance in infectious diseases and cancer. They explore how mutations in drug targets can lead to resistance and how to design better drugs that maintain their effectiveness. Using a combination of experimental and computational methods, including machine learning, the lab strives to create innovative strategies for drug development that can overcome the challenges posed by rapid evolution of pathogens.
drug resistanceHIV-1 proteasemachine learningmolecular dynamicsdrug designinfectious diseasescancer researchstructural biologyenzymes
Research Aims
5AIM 01Elucidate the molecular mechanisms of drug resistance in various pathogens.
AIM 02Develop strategies to avoid drug resistance through innovative drug design.
AIM 03Investigate the role of mutations in conferring resistance beyond the active site.
AIM 04Utilize machine learning to analyze data from drug-target interactions.
AIM 05Create robust inhibitors that remain effective against resistant variants.
Skills the Lab Values
structure-based drug design (SBDD)parallel molecular dynamics (pMD)machine learning algorithmsPCRcell cultureinhibitor characterizationmolecular modelingprotein expressionenzyme assays
Output against the department
Publications419top 12% of dept.48th of 402
this lab
most publishedleast published
Citations12ktop 42% of dept.167th of 402
this lab
most citedleast cited
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