University of South Alabama · BiochemistryAntibiotic Resistance and Bacterial Genetics Lab
Christopher Davies · Mobile, Alabama
Research Focus
Dr. Christopher Davies' lab focuses on understanding how the bacteria Neisseria gonorrhoeae becomes resistant to common antibiotics, particularly cephalosporins. By studying the mutations in a protein called PBP2, which plays a vital role in bacterial growth, the lab aims to uncover the molecular mechanisms behind this resistance. Ultimately, this research seeks to inform the development of new antibiotics to combat gonorrhea, a significant public health threat.
antibiotic resistanceNeisseria gonorrhoeaecephalosporinsPBP2 mutationspublic health
Research Aims
3AIM 01Elucidate the molecular mechanism of cephalosporin resistance in N. gonorrhoeae.
AIM 02Investigate specific interactions of PBP2 when bound by cephalosporins.
AIM 03Examine protein dynamics of PBP2 variants with resistance mutations.
Skills the Lab Values
X-Ray Crystallographymolecular dynamics simulationsprotein structure-function analysisbacterial cultureantibiotic susceptibility testing
Output against the department
Publications120bottom 32% of dept.272nd of 402
this lab
most publishedleast published
Citations24ktop 15% of dept.62nd of 402
this lab
most citedleast cited
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