University of California-Los Angeles · BiochemistryPlath Lab
Kathrin Plath · Los Angeles, California
Research Focus
Dr. Kathrin Plath's lab focuses on understanding how gene expression is regulated on the X chromosomes during embryonic development and its crucial role in the placenta's function. They specifically study X chromosome dosage compensation mechanisms and how their disruption can lead to developmental issues in embryos. By using mouse models, the lab aims to uncover the underlying processes affecting the feto-maternal interface, ultimately providing insights into female-specific developmental disorders and placental health.
X chromosome dosage compensationX-inactivationembryonic developmentplacentafeto-maternal interface
Research Aims
3AIM 01Define the role of the Xist B-repeat in placenta development.
AIM 02Explore the chromatin state in wildtype versus B-Xist models.
AIM 03Uncover mechanisms underlying junctional zone dysplasia in placentas.
Skills the Lab Values
mouse modelsRNA sequencingcell culturehistologygenetic manipulationmicroscopy
Output against the department
Publications224top 35% of dept.141st of 402
this lab
most publishedleast published
Citations32ktop 11% of dept.43rd of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.