University of California-San Diego · NeuroscienceGleeson Lab
Joseph G Gleeson · La Jolla, California
Research Focus
Dr. Joseph Gleeson's lab at the University of California, San Diego is focused on understanding the genetic and environmental factors contributing to Meningomyelocele, a common congenital condition known as Spina Bifida. The lab aims to explore how genetic mutations interact with folic acid exposure during pregnancy to influence the risk of this condition. By studying families affected by Spina Bifida, the lab seeks to identify genetic markers that could lead to better prevention and treatment strategies for this serious birth defect.
MeningomyeloceleSpina Bifidagene-environment interactionde novo mutationsfolic acid exposure
Research Aims
5AIM 01Investigate the role of de novo mutations in the risk of Spina Bifida.
AIM 02Examine the effects of folic acid supplementation on genetic risk factors for Meningomyelocele.
AIM 03Identify high-confidence risk genes associated with Spina Bifida.
AIM 04Assess genetic differences between families with and without folic acid exposure.
AIM 05Develop a multifactorial model to understand the mechanisms behind Meningomyelocele.
Skills the Lab Values
whole exome sequencingwhole genome sequencinganimal modelingdata analysisbioinformaticscell culture techniquesstatistical analysismolecular geneticstranscriptomicsclinical study design
Output against the department
Publications294top 23% of dept.154th of 671
this lab
most publishedleast published
Citations21ktop 19% of dept.128th of 671
this lab
most citedleast cited
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