University of Michigan-Ann Arbor · BiologyGABAergic Neurology Research Unit
Bing Ye · Ann Arbor, Michigan
Research Focus
Dr. Bing Ye's lab focuses on understanding the neurological features associated with Down syndrome, particularly the roles of GABAergic systems in conditions like cognitive deficits and epilepsy. The research investigates molecular regulators that may contribute to these comorbidities, using mouse models to explore the impact of specific genes, such as DSCAM. This work aims to identify therapeutic targets that could improve outcomes for individuals with Down syndrome and similar neurological disorders.
GABAergic systemsDown syndromeepilepsyneurological disordersmolecular regulationcognitive deficitsDSCAMsynaptic transmissionmouse models
Research Aims
4AIM 01Identify the molecular regulators of GABAergic systems in Down syndrome.
AIM 02Explore the relationship between cognitive deficits and epilepsy in Down syndrome.
AIM 03Characterize the activity dynamics of cell-type specific populations in the DS hippocampus.
AIM 04Utilize spatial transcriptomic techniques to analyze gene expression in DS mouse models.
Skills the Lab Values
cell culturespatial transcriptomicselectrophysiologybehavioral assaysimmunohistochemistryRNA sequencinganimal modelsdata analysis softwarehistological techniques
Output against the department
Publications93bottom 31% of dept.709th of 1,033
this lab
most publishedleast published
Citations3.5kbottom 27% of dept.758th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.