Rice University · Biomedical EngineeringBao Lab
Gang Bao · Houston, Texas
Research Focus
Dr. Gang Bao's lab at Rice University focuses on understanding and improving CRISPR/Cas9 gene editing techniques, specifically for treating sickle cell disease (SCD). They investigate unintended genetic changes that occur during the editing process and work on developing methods to minimize these effects to enhance treatment safety and efficacy. The lab's research aims to bridge the gap between innovative gene editing techniques and their clinical application, ultimately improving patient outcomes.
CRISPRgene editingsickle cell diseasegenome modificationshemopoietic stem cells
Research Aims
3AIM 01Determine the impact of large gene modifications on hemoglobin maturation in sickle cell patient cells.
AIM 02Investigate the persistence of unintended gene modifications after cell transplantation in mice and humans.
AIM 03Develop strategies to minimize large deletions during CRISPR gene editing.
Skills the Lab Values
CRISPR/Cas9cell culturegene sequencingsingle-cell RNA analysismouse models
Output against the department
Publications538top 13% of dept.80th of 595
this lab
most publishedleast published
Citations32ktop 8% of dept.47th of 595
this lab
most citedleast cited
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