University of Virginia-Main Campus · GeneticsOnengut Immunology Lab
Suna Onengut · Charlottesville, Virginia
Research Focus
Dr. Suna Onengut's lab at the University of Virginia studies type 1 diabetes (T1D), a complex autoimmune disorder. The research focuses on understanding how genetic risk factors influence the immune responses that lead to T1D, particularly through examining the interactions of immune cells and their gene expression. By utilizing advanced techniques like single-cell sequencing, the lab aims to identify biomarkers that could help predict the onset of T1D in genetically at-risk children.
Type 1 Diabetesautoimmunitysingle-cell sequencinggenetic risk factorsbiomarker discoveryimmune profilingT lymphocytesgene expression
Research Aims
5AIM 01Investigate how genetic risk variants influence immune cell behavior in type 1 diabetes.
AIM 02Utilize single-cell sequencing to profile immune response stages in T1D.
AIM 03Identify biomarkers predictive of T1D progression using participant samples from TEDDY.
AIM 04Map gene expression changes in immune cells related to T1D risk variants.
AIM 05Construct a co-expression network to explore gene interactions in immune responses.
Skills the Lab Values
single-cell sequencingcell cultureimmune cell profilinggene expression analysisBayesian network modelingbioinformaticstranscriptomicsflow cytometrygenomic analysis
Output against the department
Publications18bottom 2% of dept.254th of 259
this lab
most publishedleast published
Citations745bottom 3% of dept.252nd of 259
this lab
most citedleast cited
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