University of California-San Francisco · PharmacologyThe Ligand Lab
Brian K Shoichet · San Francisco, California
Research Focus
Professor Brian K. Shoichet's lab focuses on creating new methods for discovering potential drugs by using computational and experimental approaches. They especially aim to understand how different molecules interact with biological targets, like proteins, to influence health and disease. The lab works on large libraries of compounds to test how changes in these libraries affect drug discovery outcomes, aiming to find new insights into drug interactions and delivery methods.
ligand discoverycomputational drug designstructural biologybioinformaticspharmacology
Research Aims
4AIM 01Develop new computational methods for ligand discovery and testing.
AIM 02Investigate how different compound libraries impact drug discovery.
AIM 03Explore interactions between drugs and G-Protein-Coupled Receptors (GPCRs).
AIM 04Examine the role of colloidal aggregates in drug delivery and discovery.
Skills the Lab Values
molecular dockingdrug delivery systemschemoinformaticsbiological modelingstructural analysis
Output against the department
Publications414top 15% of dept.71st of 462
this lab
most publishedleast published
Citations55ktop 4% of dept.17th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.