Baylor College of Medicine · BiologyDi Stefano Lab
Bruno Di Stefano · Houston, Texas
Research Focus
Dr. Bruno Di Stefano's lab focuses on understanding how certain RNA processing mechanisms contribute to the development of acute myeloid leukemia (AML). The research primarily investigates a protein called DDX6, which plays a critical role in regulating RNA within cells, particularly in leukemia. By dissecting these processes, the lab aims to uncover new therapeutic targets and improve treatment strategies for patients with AML.
acute myeloid leukemiaRNA processingDDX6CRISPRgene regulation
Research Aims
3AIM 01Investigate the role of DDX6 in normal and malignant hematopoiesis using genetic mouse models.
AIM 02Characterize P-bodies in normal and leukemia cells to understand RNA sequestration.
AIM 03Analyze the translation and protein expression changes in leukemia cells following DDX6 degradation.
Skills the Lab Values
CRISPRmouse modelscell cultureRNA sequencingWestern blot
Output against the department
Publications72bottom 20% of dept.823rd of 1,033
this lab
most publishedleast published
Citations4.1kbottom 31% of dept.712th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.