Johns Hopkins University · BiologyLewy Body Mechanisms Lab
Chan-Hyun Na · Baltimore, Maryland
Research Focus
Dr. Chan-Hyun Na's lab at Johns Hopkins University focuses on understanding the mechanisms behind Lewy Body Dementia (LBD), a progressive neurodegenerative disorder that leads to cognitive and motor function decline. The lab investigates how different brain regions are affected by LBD and how specific cell types contribute to the disease. By using a mouse model that mimics human disease, the research aims to identify key cellular and molecular pathways involved in the vulnerability to LBD and similar neurodegenerative disorders.
Lewy Body Dementiasynucleinopathiesneurodegenerative diseasesbrain region vulnerabilitycell-type-specific analysis
Research Aims
5AIM 01Identify region- and cell-type-specific proteomic differences in the LBD brain.
AIM 02Examine the transcriptomic profiles of specific brain regions affected by LBD.
AIM 03Investigate the signaling pathways involved in the vulnerability to neurodegeneration in LBD.
AIM 04Utilize mouse models to mimic human LBD pathology.
AIM 05Apply integrative bioinformatics to verify findings from human brain studies.
Skills the Lab Values
mouse modelssingle-cell RNA sequencingproteomic analysisbioinformaticscell culture
Output against the department
Publications125bottom 45% of dept.567th of 1,033
this lab
most publishedleast published
Citations2.6kbottom 19% of dept.832nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.