Northwestern University · BiochemistryCarthew Lab
Richard W. Carthew · Evanston, Illinois
Research Focus
Richard W. Carthew's lab at Northwestern University studies gene regulation in developmental biology, primarily using the fruit fly Drosophila as a model organism. The research focuses on understanding the roles of non-coding RNAs, particularly long non-coding RNAs, in gene regulation and cell fate during development. Additionally, the lab investigates how external signals and tissue morphology influence cellular processes and development, utilizing advanced mathematical models and experimental techniques.
non-coding RNAslong non-coding RNAsgene regulationDrosophilacell signalingdevelopmental biologymethylationmorphogenesismathematical modeling
Research Aims
5AIM 01Investigate the molecular mechanisms of long non-coding RNAs in gene regulation.
AIM 02Explore the functional consequences of adenosine methylation in mRNAs during Drosophila development.
AIM 03Understand the interplay between tissue signaling and gene regulatory programs in embryos.
AIM 04Develop mathematical models to predict cellular behaviors in response to external signals.
AIM 05Identify how cadherin molecules influence cell orientation during tissue morphogenesis.
Skills the Lab Values
RNA sequencingmolecular biology techniquesDrosophila geneticsmathematical modelingdata analysishigh-dimensional data analysiscell cultureimmunohistochemistryquantitative experiments
Output against the department
Publications173top 50% of dept.199th of 402
this lab
most publishedleast published
Citations21ktop 19% of dept.78th of 402
this lab
most citedleast cited
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