AECAlbert Einstein College of Medicine · Biology
Breast Cancer Immunology and Stem Cells Unit
Wenjun Guo · Bronx, New York
Research Focus
Dr. Wenjun Guo's lab at Albert Einstein College of Medicine focuses on understanding how certain breast cancer cells evade the immune system and progress into aggressive cancers. The lab studies basal-like breast cancer, which significantly affects younger women and those with specific genetic backgrounds. The aim is to identify new strategies to prevent this type of cancer by targeting early-stage stem-like cells that play a crucial role in cancer development.
breast cancerimmuno-suppressionprecancer stem cellstargeted therapylineage plasticity
Research Aims
3AIM 01Investigate how SOX9 regulates immunosuppressive pathways in breast cancer precursors.
AIM 02Analyze interactions between precancer stem cells and immune cells.
AIM 03Develop therapies targeting B7x as a strategy for breast cancer prevention.
Skills the Lab Values
cell culturemouse modelsimmunohistochemistryflow cytometryRNA sequencing
Output against the department
Publications81bottom 24% of dept.781st of 1,033
this lab
most publishedleast published
Citations18ktop 21% of dept.222nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.