University of California-Davis · NeuroscienceGuo Astrocyte Lab
Fuzheng Guo · Davis, California
Research Focus
Dr. Fuzheng Guo's lab at UC Davis studies brain cells called astrocytes and their roles in health and diseases like multiple sclerosis. They focus on understanding how specific proteins, like SOX2 and PARP1, influence the function and repair of these cells in the central nervous system. The ultimate aim is to discover new ways to promote healing of damaged nerves that can help improve treatments for neurological conditions.
astrocytesCNSmultiple sclerosisSOX2PARP1myelin repairdemyelinationneuroinflammationoligodendrocytes
Research Aims
4AIM 01Investigate the role of SOX2 in astrocyte biology and its impact on neurological diseases.
AIM 02Understand how PARP1 affects the differentiation of oligodendrocyte progenitor cells.
AIM 03Explore therapeutic approaches to enhance myelin repair through targeting PARP1.
AIM 04Identify molecular mechanisms that underlie astrocyte reactive states during CNS injuries.
Skills the Lab Values
animal modelsgene knockout techniquesimmunohistochemistrycell cultureRNA sequencingtransgenic mouse generationWestern blottingPCRmicroscopystatistical analysis
Output against the department
Publications96bottom 32% of dept.457th of 671
this lab
most publishedleast published
Citations2.8kbottom 20% of dept.540th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.