Case Western Reserve University · Biomedical EngineeringNanoparticle Immunotherapy Group
Efstathios Karathanasis · Cleveland, Ohio
Research Focus
Dr. Efstathios Karathanasis's lab focuses on developing innovative nanoparticle-based therapies to improve cancer treatment, particularly for aggressive forms of the disease. The lab's research aims to reprogram the tumor microenvironment to enhance the immune response against tumors, using a combination of advanced nanoparticle techniques and immune system manipulation. By targeting specific immune checkpoints and using novel delivery methods, their work seeks to transform cancer immunotherapy and prevent tumor recurrence.
cancer immunotherapynanoparticlestumor microenvironmentimmune checkpointsmyeloid cellsT cell activationdual-action therapysiRNA deliveryTLR agoniststumor immunity
Research Aims
3AIM 01Optimize the design of dual nanoparticles to enhance immune response against tumors.
AIM 02Evaluate the safety and mechanisms of action of the nanoparticle therapy.
AIM 03Test the effectiveness of the nanoparticles as a stand-alone treatment and in combination with other therapies.
Skills the Lab Values
nanoparticle designsiRNA deliverycell culturein vivo murine modelsimmunotherapy techniquesflow cytometrymolecular biology techniquesexperimental designdata analysis using Pythonsafety profiling
Output against the department
Publications68bottom 9% of dept.542nd of 595
this lab
most publishedleast published
Citations3.1kbottom 24% of dept.454th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.