North Carolina State University at Raleigh · EngineeringZaharoff Lab
David Zaharoff · Raleigh, North Carolina
Research Focus
Dr. David Zaharoff's lab at North Carolina State University focuses on developing immunotherapies for bladder cancer that not only aid canine patients but may also benefit human treatments. Their work emphasizes the use of interleukin-12 delivered through a biopolymer to trigger immune responses against invasive bladder tumors in dogs with spontaneous cancer. The research aims to establish safety and effectiveness levels of this therapy in dogs, paving the way for potential human clinical trials in the future.
bladder cancerimmunotherapycanine modelsinterleukin-12chitosantranslational researchT cell responsesclinical trialstumor microenvironment
Research Aims
4AIM 01Evaluate the safety of intravesical CS/canine IL-12 immunotherapy in dogs with invasive bladder cancer.
AIM 02Assess the antitumor immune responses to the therapy in canine patients
AIM 03Determine the relevance of canine bladder cancer as a model for human treatments.
AIM 04Investigate the immune impacts and pharmacokinetics of the therapy.
Skills the Lab Values
cell cultureflow cytometryWestern blotanimal handlingimmunophenotypingdosing studiesdata analysisdrug administration techniquesexperimental design
Output against the department
Publications117bottom 26% of dept.207th of 278
this lab
most publishedleast published
Citations2.8kbottom 22% of dept.217th of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.