UTMThe University of Texas MD Anderson Cancer Center · Biology
Cancer Vulnerabilities Research Group
Ronald Anthony Depinho · Houston, Texas
Research Focus
Dr. Ronald Anthony Depinho's lab at the University of Texas MD Anderson Cancer Center focuses on understanding how specific gene deletions in cancer cells can create unique vulnerabilities. By identifying these weak spots, the lab aims to develop precision cancer therapies that target only cancer cells while sparing normal ones. They utilize advanced techniques such as CRISPR to explore these genetic interactions and aim to improve treatment outcomes for cancer patients.
cancer geneticscollateral lethalityCRISPRtumor suppressor genesdrug discoveryprecision medicineparalog vulnerabilitiesgenomic analysiscancer therapies
Research Aims
5AIM 01Identify collateral lethal targets in cancer cells using CRISPR technology.
AIM 02Analyze genetic deletions in tumor suppressor genes to find vulnerabilities.
AIM 03Validate candidate genes that can be targeted for cancer therapies.
AIM 04Develop precision medicine strategies based on genetic profiles of tumors.
AIM 05Translate findings into drug discovery initiatives.
Skills the Lab Values
CRISPR/Cas9 gene editingcell culturegenomic data analysisRNA sequencingdrug screeningbioinformaticsorganoid modelstumor modelsmolecular cloning
Output against the department
Publications905top 2% of dept.22nd of 1,033
this lab
most publishedleast published
Citations128ktop 1% of dept.8th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.